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Old 07-17-2015, 02:37 AM   #1 (permalink)
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Default What does Heterozygous mean?

What do test results mean when it is said the result is Heterozygous?

Specifically for ARVC and DM?
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Old 07-17-2015, 08:56 AM   #2 (permalink)
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It means the dog carries one mutated gene and one normal gene. So they are considered carriers and more at risk of developing the disease than a dog that carries 2 normal genes.

Orthopedic Foundation for Animals

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Old 07-18-2015, 12:40 PM   #3 (permalink)
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Thanks! So if a dog like this were bred to a dog that was tested negative will the babies also be negative or carriers? Is it true a carrier will never become effected?
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Old 07-18-2015, 03:49 PM   #4 (permalink)
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Thanks! So if a dog like this were bred to a dog that was tested negative will the babies also be negative or carriers? Is it true a carrier will never become effected?
The babies could be carriers or negative depending on which gene they inherit. They get one gene from each parent.

Carriers can definitely become affected.

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Old 07-18-2015, 06:46 PM   #5 (permalink)
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Carriers rarely become affected however the point of health testing to be aware of what we are producing and improve the next generations results.
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Old 07-19-2015, 11:55 AM   #6 (permalink)
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and also wondering how common it is to have to provide replacement puppies due to typical health issues laid out in a contract from a breeder? Ex. Is 3 over 12 years acceptable?
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Old 07-19-2015, 05:31 PM   #7 (permalink)
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and also wondering how common it is to have to provide replacement puppies due to typical health issues laid out in a contract from a breeder? Ex. Is 3 over 12 years acceptable?
Bunny, I really enjoyed you prior questions on heterozygous genes.
You received two great answers to your questions,saving you hours if not days of research.
But your last is a wonder to me, could you explain in detail what do you expect of a breeders contractual obligations? a twelve year span? with three supplemental pups?
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Old 07-19-2015, 05:35 PM   #8 (permalink)
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From what I get from your statement you have received 3 replacement puppies due to health issues in a 12 yr span? Wow.....that's a lot but what were the health issues you were dealing with to get a replacement to begin with?
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Old 07-19-2015, 10:57 PM   #9 (permalink)
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Sorry I guess I mistyped that. What I meant to ask is... So if a breeder makes clients sign a contract saying about how they will replace a puppy if it has congenital (I think that is what you call it when passed from the parents) and then a client's puppy died from one of those issues within the contract span, say 2 years, they replace the puppy. And that breeder has done that 3 times in the 12 years she has been breeding. Is that acceptable?

Or is that abnormal and of a breeder has been breeding that log they should have never had to replace a puppy?

Ex. 2manydogs I see you are a breeder, if one of your puppies died within your contract timelines because of health reasons that were passed from the parents, and you replaced it for the client, and this happened 3 times within your history of breeding, is that normal? Or is it abnormal?

I also wonder how many breeders would not be forthcoming with that info or lie about it to keep selling dogs??
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Old 07-19-2015, 10:59 PM   #10 (permalink)
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[QUOTE=BunnyBoxer;1794786. And that breeder has done that 3 times in the 12 years she has been breeding. Is that acceptable???[/QUOTE]

Meaning to 3 different clients not the same one
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