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Old 11-10-2011, 03:56 PM   #1 (permalink)
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Default Dam With Positive ARVC Test

Ok, here's the scoop. I found flashy fawn male puppy who's 3 weeks old right now. The breeder (reputable out of Arizona) has already emailed me all of the test results as I asked along with the answers to all of my questions. The only thing that concerns me is that the dam has tested positive for ARVC heterozygous (not sure if I'm spelling that right). Her holter and echos came back clear. The sire also had clear echo/holters and tested negative for the ARVC genes. The breeders told me that she has not lost any of her dogs to any heart related issues.

Considering that I just lost my boy to ARVC that word positive is kind of scaring me. From what I'm reading it could lead to nothing and I'm thinking that since the sire tested negative that's working for us as well. Would you consider this a reason NOT to purchase this puppy? I guess I want kind of an inbiased opinion because I think I may be overly sensitive to this ARVC test considering what I just went through.
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Old 11-10-2011, 05:48 PM   #2 (permalink)
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I'm sorry I don't have more advice for you, I am not super-familiar with ARVC but the one thing I can recommend, is to talk to your vet and maybe ask their opinion? Good luck! (sorry for your loss)
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Old 11-10-2011, 06:46 PM   #3 (permalink)
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Heterozygeous is fine, especially when bred to a clear male. Its homozygeous that you want to avoid.

EVALUATION FOR THE CANINE ARRHYTHMOGENIC RIGHT VENTRICULAR CARDIOMYOPATHY 1 MUTATION
Arrhythmogenic right ventricular cardiomyopathy (ARVC) is a fairly common form of heart disease in the Boxer dog. It is inherited and our laboratory has identified a mutation responsible for the gene in some Boxers. However, it should be noted that in human beings with the same disease, there are many different genetic mutations which can cause this disease. We do not yet know if this is the only mutation in the Boxer or if there will be many different mutations. Please keep in mind that we are continually learning about this disease and recommendations will be altered as we obtain more information.
Currently our interpretation of the test is:
Negative results:
The absence of the mutation in this dog, DOES NOT mean that it will never develop the disease. It means that it does not have the only known mutation that can cause the disease in the dog at this time.
Positive Results:
Dogs that are positive for the test will not necessarily develop significant heart disease and die from the disease. Some dogs will develop a very mild form of the disease and will live quite comfortably, some may need treatment.
Importantly, breeding decisions should be made carefully. At this time we have do not yet know what percentage of Boxers will be positive for the mutation. However, removal of a significant number of dogs from the breeding population could be very bad for the Boxer dog breed. Remember that dogs that carry this mutation also carry other important good genes that we do not want to lose from the breed.
Positive Heterozygous (1 copy of the mutated gene and 1 copy of a normal gene) Dogs that are positive heterozygous should be carefully evaluated for signs of disease (Holter monitor and possibly an echocardiogram). If an arrhythmia is detected, possible treatment options should be discussed with your veterinarian. Adult dogs that do not show signs of disease and that have other positive attributes could be bred to mutation negative dogs. Puppies may be screened for the mutation and over a few generations, mutation negative puppies may be selected to replace the mutation positive parent and gradually decrease the number of mutation positive dogs in the population.
Positive Homozygous (2 copies of the mutated gene). We recommend not breeding the homozygous dogs. Dogs that are homozygous for the mutation appear to have more significant disease and will certainly pass on the mutation.
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Old 11-10-2011, 06:47 PM   #4 (permalink)
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Thanks, from what I'm gathering this is a fairly new DNA test that's not completely fool proof. Just because the dog has the gene doesn't mean it'll turn into ARVC, but on the same hand just because they don't have this gene doesn't mean that it can't turn into ARVC either. I just don't know if I'm being super sensitive to this or not considering I just lost my boy to ARVC. If I hadn't just lost him, I probably wouldn't even be giving this much though actually.
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Old 11-10-2011, 06:47 PM   #5 (permalink)
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I just posted a thread with a great video that explains ARVC. It's lengthy, but important. I still haven't watched the entire video, but I think it may help you understand ARVC and what the health test results mean. https://www.boxerforums.com/breeding-...h-testing.html


Quote:
Considering that I just lost my boy to ARVC that word positive is kind of scaring me
Skip to about the 1:04 hour mark.. It explains the percentage rate of affected ARVC+ dogs.
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Old 11-10-2011, 06:48 PM   #6 (permalink)
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Woah... that was weird. We were posting at the same time! Thanks for that info.
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Old 11-10-2011, 07:39 PM   #7 (permalink)
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Holters and family history are a far better indicator of ARVC risk at this point. There have been numerous ARVC negative dogs that developed ARVC and numerous ARVC positive dogs -- homozygous and heterozygous -- that never developed the disease. A family history of longevity coupled with multiple clear holters will give you the best chances of a healthy, long-lived puppy.
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Old 11-11-2011, 05:00 PM   #8 (permalink)
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Thanks for the info everyone.

Both parents had clean holters and echos and the breeder says she's never lost a dog due to heart related issues.

Since this ARVC test isn't a sure thing either way, I decided to make a deposit on this little boy. He will be 8 weeks old on 12/14 so I have about a month to go before he comes home.
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Old 11-11-2011, 05:03 PM   #9 (permalink)
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Quote:
Originally Posted by Ril-Mas View Post
Thanks for the info everyone.

Both parents had clean holters and echos and the breeder says she's never lost a dog due to heart related issues.

Since this ARVC test isn't a sure thing either way, I decided to make a deposit on this little boy. He will be 8 weeks old on 12/14 so I have about a month to go before he comes home.

Yay - can't wait to see some pics !!!!!
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