Writing back finally. The magic/smoke and mirrors of medicine seem to point that the liver issues were due to toxicity to the Apequel (Allergy meds). My vet thought the skin issues on our dog's anus and snout were allergies but in fact were lymphoma. We are now on a chemotherapy protocol and he is in remission at 3.5 years old.Please don't automatically listen to your vet, if you have a gut feeling go with it. A simple test would have saved us exploratory surgery, liver issues and possibly added a few more months to our fur-child's life.