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Discussion Starter #1 (Edited)
Boomerang member here - owner of 2 wonderful boxers. One almost 7 white male (Cotton) and one fawn male (Murray) - rescue, no idea of age. Thinking 9-10.

Since early June, Murray has been PU/PD for no apparent reason. He’s always been a big water drinker and looking back I can say his intake seemed to increase over the past few months. It came to a head when he couldn’t hold it overnight and would pee in his sleep. Since then, we’ve been to two vets in Richmond (one being an internal specialist) for complete blood work, including thyroid and tick borne analysis, Urinalysis (2x as first wouldn’t concentrate), ultrasound (slightly enlarged adrenal glands which they say is probably normal for him), SDMA for early kidney disease, ACTH for Cushing - you name it, we’ve done it and it’s all come up negative.

I will say he’s had back and hip issues, but an X-ray there came out clean as well. Rimadyl seems to help - but we’re up to 100mg 2x a day which I know is top of the board for his size (80lbs). Also doing acupuncture and some herbal supplements. He’s had auto-immune issues in the past with his skin and was on pentoxifylline for about a year. Went off that in April/Early May but vet doesn’t think that’s an issue. He’s also been pretty lethargic, not wanting to play.

Right now we’re letting him have all the water he wants (10-13 cups a day depending if they’re outside) and he wears a band in the house. Sorry for all the details, the vets just are stuck and want to treat as pain. Any thoughts on something we may be missing or do I just have an older guy who needs love?
 

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So sorry for Murrays problems. To me and I am by no means that medically knowledgeable but it sounds like you have checked just about everything. When you say increased water intake I always think diabetic but my guess it that was also checked. Murray being 9 or 10 I think you are lucky and he is a bit of an old guy. I'm sure you will hear from others more knowledgeable.
 

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Thanks! That article helps as we can look back and see the increased drinking coming on so have some thoughts on what to do. Either way, seems medications can do more damage then good so looking at holistic options. Appreciate it!
 

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Yep, he’s negative for almost any disease you come up with! His blood work is practically perfect, just slightly high cholesterol. I’ve talked to many people who say they had similar issues with their dogs and couldn’t get it diagnosed, turning out to be Cushings each time. The meds actually do a lot of damage so working my vet for holistic approach including herbs and Acupuncuture.
 
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