Well I don't know exactly where to begin. Me and my fiance have a Boxer she is roughly around 4-5 years old and has severe allergies/issues to just about everything. He purchased her at a local pet shop when she was a puppy and she was fine until she hit about 6 months old and has had problems ever since then. We have spent thousands on her to try and figure out the issues to no avail. She has been prescribed apoquel 16mg tablets 1-2x a day along with 6 benadryl (we have tried various other antihistamines as well), she has also been on prednisone which didn't work to well and she was constantly peeing all over the house because of it. We have also tried Cytopoint (sp) injection for allergy and she broke out in hives so bad she looked like bubble wrap for two weeks and had bloody stools. She gets bathed with a special prescription shampoo as well. She gets chronic ear infections and we can't get her ears to heal for the life of us. She has also been tested for allergies and it came back that she has a severe allergy to mites and fleas which we do use a product to prevent that. She shakes her head so much she is literally breaking open her ears on a daily basis, she will rub her face and chin on anything she can as well until she is bleeding and will continually lick her paws until they are red and raw. Our house is in a constant state of blood shed with her. We have changed her diet going through different proteins from chicken, beef, lamb, all types of fish, bison, kangaroo, grain free, canned, raw; and nothing is seeming to help her. Short of making her live in her e-collar forever and or be in a sedated state for the rest of her life we don't know what else to do with her. She is constantly miserable and we don't like having to continually yell at her and or use her e-collar to make her stop. Has anyone else had any success with any other treatments we are desperate.