Tries to KILL herself!

God, thats awful.  I've never heard of a case of SA that bad.   My puppy developed separation anxiety early on, I had to ween him off of it.  It wasn't nearly that bad but I was unable to crate him because I was afraid he was going to hurt himself.  He did rip apart some couch cushions.  But I gradually was able to get him to the point where he can stay home alone and be fine.   It took a lot of work.  I also am home all day so I think they get spoiled, they don't understand we like to have a life on the weekends!  I'm sure you've tried a lot of things, I'm just wondering if you started at the basic level:   Leaving her in a room alone while you are home.  Even if just for 5 minutes a day.  Thats what really got me to the next level with my boy, he was just so used to being with me all day that he couldn't stand it if I left the room.  I decided to separate him for a few minutes a day.  Then increase it to 10 mins the next week.  Then leaving the house for 2 minutes a day.  Then 5 minutes.  So on and so forth.  The exact times aren't really important, just starting from scratch.  The idea is to return before the anxiety sets in so the separation doesn't give them a negative association.  Usually once they realize you will always come back eventually, they are ok.  I've read that once you can leave them alone for 30 mins, they can be left for longer, because the worst SA usually sets in right after you leave.  I went from a dog that would freak out if I went to the bathroom to a dog that could be left alone for 8 hours sleeping on the couch.  Wasn't easy though.

I'm also wondering how much exercise she gets.  Sometimes running around in the yard isn't enough.  Have you tried really getting her tired out (I'm talking like a playdate with other dogs for a few hours) and then leaving her alone?  If you could tire her out so much just once and then get her to be ok alone for a little bit, that could be a huge first step.  

I always enjoy this issue because I'm still learning about it myself.  But it's very possible there just may be cases (perhaps yours) that are beyond basic treatment.

OMG, I was having dejavue listening to your story. Ok, my very first boxer did the same thing. He ate through two airline crates, then I got him the all metal cage. Well, he could somehow move that crate around my condo. He ate through 6 sets of vertical blinds on my sliding door, any couch pillows he could get a hold of and that was all while he was in the darn crate!! He also chewed the trim off the front door, opened the oven, opened and took all the clothes out of my dresser drawers. It was incredible. I was recently divorced and working two jobs - I was about to have a nervous breakdown. Well, someone told me a about this pet psychic (I know, sounds crazy) and I finally broke down and called her. It was the best $60 I ever spent. She told me that he was lonely and needed a companion as well as more exercise. Well, I started walking him at least two miles a day and got him a kitten - do you know that he never tore up another thing in that apt and ended up being one of the smartest animals I have ever had!

Welcome aboard Shannon! Boy, I wish you had better news for us on your first post!

My first boxer had severe seperation anxiety also. I never put him on clomicalm or any other meds for it though, I just worked through it. He too would break out of his crate and destroy things in the house. Chewed up some rugs, destroyed doors, he was a mess. When I did try to keep him in his crate using cable ties so he could not get out, I would come home to a disgusting mess of him and his crate. He would get himself so worked up in the crate, he would throw up, and believe me when I say it was like projectile vomit....it was everywhere. I finally came to the conclusion that he could not be crated, so I pretty much doggy proofed the house before I left. I would close all doors to bedrooms and bathrooms. Remove anything of value, or anything chewable. I guess that was the reason some of my rugs, baseboards, and doors got destroyed!
When you do start to leave the house, do it in small intervals at a time. With Sadie, it does sound like she does have an extreme case, so you will need to work slowly with her. When you first start to leave, just go out the door for a few seconds then come back in. If she seems ok, lenghthen the time you leave everytime.  
Work up to a two minute leave to the mailbox. Then add minutes as the days progress. When you leave, just leave. Do not give her any special attention, just say Ok Sadie, I'll be back, and leave. When you return, ignore her. Do not make eye contact with her for the first few minutes. Read the mail, go to the bathroom, whatever, again make it no big deal. Eventually you can give her a pat on the head and say I'm back. Do this each and every time you leave the house. Also, what Sully said, it is a great idea to get them really tired before you leave. A tired boxer, is a well behaved boxer.
When you start leaving her, you can leave a radio or TV on for her and also give her a tshirt that has your scent on it. When you return, if she did do some form of destruction, do not punish her, that can actually make the SA worse. Just clean it up and move on. SA is a panic response when you leave so you need to desensitize that feeling of panic.
I think you can work this through, but everyone in the house has to be on the same page and practice the exact same things as you with Sadie. Good Luck with this. I know how frustrating it is, and let us know how she is progressing.  

First I'd like to thank all of you for your responses!  I have tried all of your ideas.  That's why I'm at such a loss.  As I said before, she is SOOOOOOO much better on the clomicalm...but my problem is when it's time to take her off.  Every time I try to lower the dosage, it's back to the same thing.  I also have a american bulldog/boxer mix.  I rescued him from petfinder when he only had a couple hours left to live.  They descriminated against him due to him having american bulldog in him and they said bully breeds were not trustable!  HA!  He had also been shot in the thigh, a broken knee, other knee cap is permantly dislocated and he's deaf!  So he was deemed unadoptable!  Well he came home w/ me!!!  I tell you what!  He's the BEST dog I have ever met!!!  He's just like Eyor (from winnie the pooh)!  So calm and layed back!  I just wish Sadie Mae was half as calm as him!  He swears he's a human!  Sits on the couch just like a human too!  As for Sadie, I guess time will only tell once the vet decides it's time for her to ween off the clomicalm.  I don't know what I'll do if she reverts back to the same severe behavior!  I've even tried contacting the "Dog Wisperer"!!!  AHHHHHHH!!!!  When she's laying on my lap looking up at me w/ those boxer eyes full of love...I just melt and can't imagine being w/out her!

Hi Shannon. Please be very careful weening her off of Clomicalm. Antianxiety drugs can be pretty evil (benzodiazepines). I was on them for only 3 months (lorazapam) for anxiety problems I have. I stopped cold turkey, my doctor never told me I had to ween off of them, which would of lessened my withdraw. My withdraw was a living h*ll. Hot/cold flash's, nausea, no appitite, couldnt sleep for 2 weeks (your body will force itself to sleep at this point), very irritable, horrid nightmares, I couldnt even comprehend 5+3 without getting totally confused, tremors/muscle twitching constantly, no energy, depression, sharp electrical noises inside my head, hearing voices, increased anxiety every morning and most of the day, it felt like the rest of the world was zooming by while I was stuck in a slow daze. I thought I was going literally crazy. I even went to the ER because I thought I was dying, they said I was perfectly healthy (Dr's know little of the withdraw from these drugs, they just know how to hand them out like candy). I layed in bed for the first 3 months in a fetal position wishing I would die. I even got rid of my firearms because I became so down on life. My withdraw symptoms lasted about a year. I was poisoned by people that I thought were helping me.

I would imagine the withdraw would be the same with animals being its the same kind of drug. Heres a link to Benzodiazepine withdraw, for humans, http://www.benzo.org.uk/manual/ Maybe reading this would give you some insight of what goes on with the drug inside of the brain and body, and help you somewhat deal with the problem of getting Sadie Mae off the drugs.

One of the reasons I got Seven (my boxer) is to help me through my withdraw, and because my family has had a few boxers growing up, I just love them! He helped me have a purpose in life again, a reason to get up. He was always there for me with a wagging nub! He saved my life! I owe him my life and the best life a boxer could ever have.

Im glad youre not giving up on Sadie Mae, I know she wouldnt give you up!

I wish you the best, and my heart goes out to you and Sadie Mae. Im sorry if theres no easy fix.

Hello all!  Thank you again for trying to help me & Sadie Mae out!  For those that suggested the natural herbal sups...they did absolutaly nothing for her!  Clomicalm has been her miracle drug!
I'm guessing that she'll just have to be on it until the vet feels it's time to ween her off.  I just wish she was all better and didn't need the meds anymore!  I've heard that long term use of it causes permanate kidney and liver damage!!!!  That's what worries me!  But at this point there is no other alternative!  I'm trying to exercise her alot more to get out her pent up energy!  Lord knows she has alot of it!  But I think that every person that owns a boxer knows how that is!  Every time the thought of finding a new home for her enters my brain...I just look at her and know she's right where she's supposed to be!  She's one of my kids!  I will never give up on her!!!  We took her to the doggy park Saturday and she thought she was in heaven!!!  DIRTY but HAPPY!  My boy Jacob was violated though!  HA!  A HUGE great dane decided Jacob would be his "mating" partner even though he's a boy!  Poor Jacob didn't know what to do!  The owner of the GD finally took the dog and left the park because he felt so bad for my boy!

do you have her on a strict routine? I can only advise what has worked for me. I used to rehab all bully breeds and have had great success doing so.
First thing in the morning make time to take her on a run, or a fast paced walk. No less than one hour. On your half way point start doing different training commands and DO NOT THINK NEGATIVE for any reason. If you anticipate her tearing up your home she will. Keep it light and simple. Picture her sleeping on the sofa instead of shredding it. After returning home, feed her and give meds as usual. then practice for two minutes walking out the door with her in a sit-stay position. and praise her when you return for not freaking out. then as they said previously make it longer and longer. In the event she does make a mess in your trials, don't get upset, just praise her anyways and keep on doing what you were going to do. when you return home from anything take her for a short quick walk. spend time praising her and letting her know you love her.
It just sounds like your dog is insecure and it may sound mean, but she doesn't see you as boss. Ceasar would tell you lay her down and roll her over on her back and make her stay there until she relaxes, at the very moment she does give her a massage. Don't ever come to her in a high pitched squeaky voice as dogs do not respond to anyone that they deem as not the boss. Always be calm and assertive in all situations that you put you and your dog through and your dog will do the same, and respond graciously.
It kinda sounds like your dog needs something to do. She isn't afraid you will not come back, she is upset she cannot go with. Dogs live in packs and are constantly moving. When you take her on walks, put a pack on her and let her carry your water. It gives her a purpose. Once you have her on a strict routine she will anticipate the next objective and always know what is going to happen. THerefore having less and less episodes. I hope what I have said is helpful, and good luck with your ventures!